|First Appearance||Shikigami no Shiro III|
A fairly enigmatic girl, Nagino appears to be a carefree elementary school student investigating Alcaland for fun. She enjoys toying with Kohtaro Kuga and Gennojo Hyuga's relationships, and calls them both 'papa'. (She addresses both Sayo Yuuki and Fumiko Odette Van Stein as 'mama'.) Her rabbit is known as Strider, and goes everywhere Nagino does.
However, her happy-go-lucky mood is merely a facade. She is actually the human incarnation of a powerful deity of some sort, which the game gives very little detail on.
- Nagino uses the same Shikigami and Bomb attacks as Niigi Gorgeous Blue from Shikigami no Shiro II.
- Nagino is voiced by the same actress that voices Emilio Stanburke in the US version, Mela Lee; an actress also notable for being the voice of Rachel Alucard in BlazBlue.
- In the Japanese version of Shikigami no Shiro III, Nagino Ise has an image of Bub from Bubble Bobble on her backpack. Nagino's alternative color scheme for the second player instead displays Bob from the same game. This is because Taito is the publisher of the original Japanese arcade version.
- My Shikigami is called Strider!
- Leave or be trampled upon. It's your duty as the opponent to choose one.
|Protagonists||Kohtaro Kuga · Sayo Yuuki · Gennojo Hyuga · Fumiko Odette Van Stein (Chibi) · Kim Dae-jeong · Niigi Gorgeous Blue · Roger Sasuke · Emilio Stanburke · Batu Harai · Mihee Kim · Reika Kirishima · Nagino Ise · Munchausen · Tagami|
|Supporting Characters||Sazae · Neko · Moonsong · Devourer · Strider|
|Antagonists||Aku Miyoko · Juu Fujishima · Aku Hiroshi · Aku Bauman · Shoujo · Arala Cran · Anolegos Dundeon · Ajo Brothers · Yukari Horiguchi · Shintaro Kuga · Shikou Mibuya · Freedom Wind · Kagachi · Tsukiko Johjima|